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Current Research

 • Degradable Thin Films

 • Polymers for Gene Delivery

Selected Publications

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Lynn Research Group - Department of Chemical and Biological Engineering

Selected Research Publications

Ph.D. Work at Caltech (1994 – 1999):

  1. Lynn, D. M.; Kanaoka, S.; Grubbs, R. H. "Living Ring-Opening Metathesis Polymerization in Aqueous Media Catalyzed by Well-Defined Ruthenium Carbene Complexes." Journal of the American Chemical Society 1996, 118, 784-790.
     
  2. Mohr, B.; Lynn, D. M.; Grubbs, R. H. "Synthesis of Water-Soluble, Aliphatic Phosphines and Their Application to Well-Defined Ruthenium Olefin Metathesis Catalysts." Organometallics 1996, 15, 4317-4325.
     
  3. Lynn, D. M.; Mohr, B.; Grubbs, R. H. "Living Ring-Opening Metathesis Polymerization in Water." Journal of the American Chemical Society 1998, 120, 1627-1628.
     
  4. Kirkland, T.A.; Lynn, D.M.; Grubbs, R.H. "Ring-Closing Metathesis in Water and Methanol." Journal of Organic Chemistry 1998, 63, 9904-9909.
     
  5. Grubbs, R.H.; Lynn, D.M. "Olefin Metathesis in Water" in Aqueous-Phase Organometallic Catalysis: Concepts and Applications (B. Cornils, W. Herrmann, Eds.), Wiley-VCH, New York, 1998, pp. 466-476.
     
  6. Lynn, D. M.; Mohr, B.; Grubbs, R. H.; Henling, L. M.; Day, M. W. "Water-Soluble Ruthenium Alkylidenes: Synthesis, Characterization, and Application to Olefin Metathesis in Protic Solvents." Journal of the American Chemical Society 2000, 122, 6601-6609.
     
  7. Lynn, D. M.; Grubbs, R. H. "Novel Reactivity of Ruthenium Alkylidenes in Protic Solvents: Degenerate Alkylidene Proton Exchange." Journal of the American Chemical Society 2001, 123, 3187-3193.

Postdoctoral Work at MIT (1999 – 2002):

  1. Lynn, D. M.; Langer, R. "Degradable Poly(ß-Amino Esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA." Journal of the American Chemical Society 2000, 122, 10761-10768.
     
  2. Lynn, D.M.; Amiji, M.M.; Langer, R. "pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material Within the Range of Intracellular pH." Angewandte Chemie International Edition 2001, 40, 1707-1710.
     
  3. Lynn, D. M.; Anderson, D. G.; Putnam, D.; Langer, R. "Accelerated Discovery of Synthetic Transfection Vectors: Parallel Synthesis and Screening of a Degradable Polymer Library." Journal of the American Chemical Society 2001, 123, 8155-8156.
     
  4. Zelikin, A.N.; Lynn, D.M.; Farhadi, J.; Martin, I.; Shastri, V.P.; Langer, R. "Erodible Conducting Polymers for Potential Biomedical Applications." Angewandte Chemie International Edition 2002, 41, 141-144.
     
  5. LaVan, D.; Lynn, D.M.; Langer, R. "Moving Smaller in Drug Discovery and Delivery." Nature Reviews Drug Discovery 2002, 1, 77-84.
     
  6. Potineni, A.; Lynn, D.M.; Langer, R.; Amiji, M.M. "Poly(ethylene oxide)-Modified Poly(ß-amino ester) Nanoparticles: A Long-Circulating pH-Sensitive Biodegradable System for Paclitaxel Delivery." Journal of Controlled Release 2003, 86, 223-234.
     

  7. Akinc, A. B.; Lynn, D. M.; Anderson, D. G.; Langer, R. "Parallel Synthesis and Biophysical Characterization of a Degradable Polymer Library for Gene Delivery" Journal of the American Chemical Society 2003, 125, 5316-5323.

  8. Anderson, D. G.; Lynn, D. M.; Langer, R. "Semi-Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery." Angewandte Chemie International Edition 2003, 42, 3153-3158.

  9. Akinc, A. B.; Anderson, D. G.; Lynn, D. M.; Langer, R. "Synthesis of Poly(ß-amino ester)s Optimized for Highly Effective Gene Delivery." Bioconjugate Chemistry 2003, 14, 979-988.

  10. Berry, D.; Lynn, D. M.; Sasisekharan, R.; Langer, R. "Poly(ß-amino ester)s Promote Cellular Uptake of Heparin and Cancer Cell Death." Chemistry and Biology 2003, 11, 487-498.

  11. Little, S. R.; Lynn, D. M.; Ge, Q.; Anderson, D. G.; Purnam, S. V.; Chen, J.; Eisen, H.; Langer, R. "Poly(ß-amino ester)-Containing Microparticles Enhance the Activity of Non-Viral Genetic Vaccines." Proceedings of the National Academy of Sciences, USA 2004, 101, 9534-9539.

  12. D. M. Lynn, D. G. Anderson, A. B. Akinc, and R. Langer, “Degradable Poly(ß-amino ester)s for Gene Delivery.” in Polymeric Gene Delivery: Principles and Applications (M. Amiji, Ed.), CRC Press, New York, 2004, 227-241.

  13. S. R. Little, D. M. Lynn, S. V. Puram, and R. Langer, “Formulation and Characterization of Poly(ß-amino ester) Microparticles for Genetic Vaccine Delivery.” Journal of Controlled Release 2005, 107, 449-462.

  14. D. Berry, D. M. Lynn, E. Berry, R. Sasisekharan, and R. Langer, "Heparin Localization and Fine Structure Regulate Burkitt's Lymphoma Growth." Biochemical and Biophysical Research Communications 2006, 348, 850-856.

Research at UW – Madison (2002 – Present):

  1. Vázquez, E.; DeWitt, D. M.; Hammond, P. T.; Lynn, D. M. "Construction of Hydrolytically-Degradable Thin Films via Layer-by-Layer Deposition of Degradable Polyelectrolytes." Journal of the American Chemical Society 2002, 124, 13992-13993.
     
  2. Gelman, M. A.; Weisblum, B.; Lynn, D. M.; Gellman, S. H. "Biocidal Activity of Polystyrenes that are Cationic by Virtue of Protonation." Organic Letters 2004, 6, 557-560.
     
  3. J. Zhang, L. S. Chua, and D. M. Lynn, "Multilayered Thin Films that Sustain the Release of Functional DNA Under Physiological Conditions." Langmuir 2004, 20, 8015-8021.
     
  4. K. Wood, J. Q. Boedicker, D. M. Lynn, and P. T. Hammond, "Tunable Drug Release from Hydrolytically Degradable Layer-by-Layer Thin Films." Langmuir 2005, 21, 1603-1609.
     
  5. N. J. Fredin, J. Zhang, and D. M. Lynn, "Surface Analysis of Erodible Multilayered Polyelectrolyte Films: Nanometer-Scale Structure and Erosion Profiles." Langmuir 2005, 21, 5803-5811.
     
  6. C. M. Jewell, J. Zhang, N. J. Fredin, and D. M. Lynn, "Multilayered Polyelectrolyte Films Promote the Direct and Localized Delivery of DNA to Cells." Journal of Controlled Release 2005, 106, 214-223.
     
  7. X. Liu, J. W. Yang, A. D. Miller, E. A. Nack, and D. M. Lynn, "Charge-Shifting Cationic Polymers that Promote Self-Assembly and Self-Disassembly with DNA." Macromolecules 2005, 38, 7907-7914.
     
  8. N. L. Abbott, C. M. Jewell, M. E. Hays, Y. Kondo, D. M. Lynn, "Ferrocene-Containing Cationic Lipids: Influence of Redox State on Cell Transfection." Journal of the American Chemical Society 2005, 127, 11576-11577.
     
  9. J. Zhang, N. J. Fredin, J. F. Janz, B. Sun, and D. M. Lynn, "Structure/Property Relationships in Erodible Multilayered Films: Influence of Polycation Structure on Erosion Profiles and the Release of Anionic Polyelectrolytes." Langmuir 2006, 22, 239-245.
     
  10. D. M. Lynn, "Layers of Opportunity: Nanostructured Polymer Assemblies for the Delivery of Macromolecular Therapeutics." Soft Matter 2006, 2, 269-273.
     
  11. C. M. Jewell, M. E. Hays, Y. Kondo, N. L. Abbott, and D. M. Lynn, "Ferrocene-Containing Cationic Lipids for the Delivery of DNA: Oxidation State Determines Transfection Activity." Journal of Controlled Release 2006, 112, 129-138.
     
  12. K. C. Wood, H. F. Chuang, R.D. Batten, D. M. Lynn, and P. T. Hammond, "Controlling Interlayer Diffusion to Achieve Sustained, Multi-Agent Delivery from Layer-by-Layer Films." Proceedings of the National Academy of Sciences, USA 2006, 103, 10207-10212.
     
  13. J. Zhang, N. J. Fredin, and D. M. Lynn, "Erosion of Multilayered Assemblies Fabricated from Degradable Polyamines: Characterization and Evidence in Support of a Mechanism that Involves Polymer Hydrolysis." Journal of Polymer Science - Part A: Polymer Chemistry 2006, 44, 5161-5173.
     
  14. C. M. Jewell, J. Zhang, N. J. Fredin, M. R. Wolff, T. A. Hacker, and D. M. Lynn, "Release of Plasmid DNA from Intravascular Stents Coated with Ultrathin Multilayered Polyelectrolyte Films." Biomacromolecules 2006, 7, 2483-2491.
     
  15. J. Zhang and D. M. Lynn, "Multilayered Films Fabricated from Combinations of Degradable Polyamines: Tunable Erosion and Release of Anionic Polyelectrolytes." Macromolecules 2006, 39, 8928-8935.
  1. N. J. Fredin, J. Zhang, and D. M. Lynn, "Nanometer-Scale Decomposition of Ultrathin Multilayered Polyelectrolyte Films." Langmuir 2007, 23, 2273-2276.

  1. C. M. Jewell, S. M. Fuchs, R. M. Flessner, R. T. Raines, and D. M. Lynn, “Multilayered Films Fabricated from an Oligoarginine-Conjugated Protein Promote Efficient Surface-Mediated Protein Transduction.” Biomacromolecules 2007, 8, 857-863.

  2. M. E. Hays, C. M. Jewell, D. M. Lynn, and N. L. Abbott, "Reversible Condensation of DNA Using a Redox-Active Surfactant." Langmuir 2007, 23, 5609-5614.

  3. M. E. Hays, C. M. Jewell, Y. Kondo, D. M. Lynn, N. L. Abbott, "Lipoplexes Formed by DNA and Ferrocenyl Lipids: Effect of Lipid Oxidation State on Size, Internal Dynamics and Zeta-Potential." Biophysical Journal 2007, 93, 4414-4424.

  4. B. Sun, C. M. Jewell, N. J. Fredin, D. M. Lynn, "Assembly of Multilayered Films Using Well-Defined, End-Labeled Poly(acrylic acid): Influence of Molecular Weight on Exponential Growth in a Synthetic Weak Polyelectrolyte System." Langmuir 2007, 23, 8452-8459

  5. M. I. Kinsinger, B. Sun, N. L. Abbott, and D. M. Lynn, "Reversible Control of Ordering Transitions at Aqueous/Liquid Crystal Interfaces Using Functional Amphiphilic Polymers." Advanced Materials 2007, 19, 4208-4212.

  6. M. E. Buck, J. Zhang, and D. M. Lynn, "Layer-by-Layer Assembly of Reactive Ultrathin Films Mediated by 'Click'-Type Reactions of Poly(2-Alkenyl Azlactone)s." Advanced Materials 2007, 19, 3951-3955.

  7. J. Zhang and D. M. Lynn, "Ultrathin Multilayered Films Assembled from 'Charge-Shifting' Cationic Polymers: Extended, Long-Term Release of Plasmid DNA from Surfaces." Advanced Materials 2007, 19, 4218-4223.

  8. D. M. Lynn, "Peeling Back the Layers: Controlled Erosion and Triggered Disassembly of Multilayered Polyelectrolyte Thin Films." Advanced Materials 2007, 19, 4118-4130.

  9. J. Zhang, S. I. Montañez, C. M. Jewell, and D. M. Lynn, "Multilayered Films Fabricated from Plasmid DNA and a Side-Chain Functionalized Poly(ß-amino ester): Surface-Type Erosion and Sequential Release of Multiple Plasmid Constructs from Surfaces." Langmuir 2007, 23, 11139-11146.

  10. J. Zhang, N. J. Fredin, and D. M. Lynn, "Apparent Dewetting of Ultrathin Multilayered Polyelectrolyte Films Incubated in Aqueous Environments." Langmuir 2007, 23, 11603-11610.

  11. C. M. Jewell and D. M. Lynn, "Multilayered Polyelectrolyte Assemblies as Platforms for the Delivery of DNA and Other Nucleic Acid-Based Therapeutics." Advanced Drug Delivery Reviews 2008, 60, 979-999.

  12. C. L. Pizzey, C. M. Jewell, M. E. Hays, D. M. Lynn, N. L. Abbott, Y. Kondo, S. Golan, and Y. Talmon, “Characterization of the Microstructure of Complexes Formed by a Redox-Active Cationic Lipid and DNA.” Journal of Physical Chemistry B 2008, 112, 5849-5857.

  13. C. M. Jewell and D. M. Lynn, “Surface-Mediated Delivery of DNA: Cationic Polymers Take Charge.” Current Opinion in Colloid and Interface Science 2008, 13, 395-402.

  14. X. Liu, J. Zhang, and D. M. Lynn, “Polyelectrolyte Multilayers Fabricated from ‘Charge-Shifting’ Anionic Polymers: A New Approach to Controlled Film Disruption and the Release of Cationic Agents from Surfaces.” Soft Matter 2008, 4, 1688-1695.

  15. X.Liu, J.W. Yang, and D. M. Lynn, "Addition of 'Charge-Shifting' Side Chains to Linear Poly(ethyleneimine) Enhances Cell Transfection Efficiency." Biomacromolecules 2008, 9, 2063-2071.

  16. X. Liu, J. Zhang, and D. M. Lynn, "Ultrathin Multilayered Films that Promote the Release of Two DNA Constructs with Separate and Distinct Release Profiles." Advanced Materials 2008, 20, 4148-4153.

  17. C. M. Jewell, M. E. Hays, Y. Kondo, N. L. Abbott, and D. M. Lynn, "Chemical Activation of Lipoplexes Formed from DNA and a Redox-Active, Ferrocene-Containing Cationic Lipid." Bioconjugate Chemistry 2008, 19, 2120-2128.

    18.

  18. M. I. Kinsinger, M. E. Buck, F. Campos, D. M. Lynn, and N. L. Abbott, "Dynamic Ordering Transitions of Liquid Crystals Driven by Interfacial Complexes Formed Between Polyanions and Amphiphilic Polyamines." Langmuir 2008, 24, 13231-13236.

  19. E. M. Saurer, C. M. Jewell, J. M. Kuchenreuther, and D. M. Lynn, "Assembly of Erodible, DNA-Containing Thin Films on the Surfaces of Polymer Microparticles: Toward a Layer-by-Layer Approach to the Delivery of DNA to Antigen-Presenting Cells." Acta Biomaterialia 2009, 5, 913-924.

  20. N. J. Fredin, A. H. Broderick, M. E. Buck, and D. M. Lynn, "Nano-Imprinted Thin Films of Reactive, Azlactone-Containing Polymers: Combining Methods for the Topographical Patterning of Cell Substrates with Opportunities for Facile Post-Fabrication Chemical Functionalization." Biomacromolecules 2009, 10, 994-1003.

  21. M. E. Buck, A. S. Breitbach, S. K. Belgrade, H. E. Blackwell, and D. M. Lynn, "Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-Alkenyl Azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth." Biomacromolecules 2009, 10, 1564-1574.

  22. M. I. Kinsinger, M. E. Buck, M. V. Meli, N. L. Abbott, and D. M. Lynn, "Langmuir Films of Flexible Polymers Transferred to Aqueous/Liquid Crystal Interfaces Induce Uniform Azimuthal Alignment of the Liquid Crystal." Journal of Colloid and Interface Science 2009, In press.

  23. M. E. Buck and D. M. Lynn. "Reactive Layer-by-Layer Assembly of Suspended Thin Films and Semi-Permeable Membranes at Interfaces Created Between Aqueous and Organic Phases." Advanced Materials 2009, In press.

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